In the South Korean cosmetic medicine industry, PDRN (Polydeoxyribonucleotide) is recognized as the "cornerstone of skin repair" and is the key ingredient in what is commonly referred to as "salmon injections."
Simply put, PDRN is not a "filler" like hyaluronic acid, nor a "wrinkle reducer" like Botox; it is a regenerative material.
✅ What is PDRN?
PDRN is a DNA fragment extracted from the testes of salmon.
Why salmon? Because the DNA sequence of salmon is over 95% similar to human DNA. This means that once it enters the human body, there is almost no risk of rejection, making it extremely safe.
Its role: If damaged skin is likened to a broken house, hyaluronic acid serves as the putty to fill the gaps, while PDRN acts as the "repairman" who brings in the bricks for construction. It works directly at the cellular level, activating the skin's self-repair mechanisms.
✅ Core Benefits: More Than Just Hydration
Many Korean women are advised by doctors to use PDRN after laser treatments, chemical peels, and other ablative procedures for the following reasons:
Deep Repair: Accelerates the healing of damaged skin barriers, particularly suitable for sensitive skin and those with rosacea.
Anti-inflammatory and Redness Reduction: Significantly decreases skin inflammation, providing excellent repair effects on acne scars and redness following allergies.
Promotes Collagen Regeneration: Stimulates fibroblast regeneration, resulting in thicker, healthier skin that reveals a "robust texture" from within.
Improves Skin Texture: Minimizes pores, smooths fine lines, and creates a so-called "natural glow."
✅ A Common Misconception: PDRN vs. PN (Rejuran)
Many people struggle to differentiate between PDRN and Rejuran.
PDRN: Smaller molecular weight, focusing on "anti-inflammatory and rapid repair," metabolizes quickly, and is relatively affordable.
PN (Polynucleotide): The core ingredient of Rejuran. It is an "enhanced" version of PDRN, with a longer chain and larger molecular weight. PN remains in the skin longer, focusing on **"structural restructuring and overall anti-aging."**
In summary: Choose PDRN for quick redness reduction and wound repair; opt for PN for long-lasting anti-aging and increased skin thickness.
✅ New Trends in PDRN in
